Research Symposium Agenda

Agenda as of June 19, 2026. Subject to change. All session times are in Mountain Time (MT).

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Tuesday, July 28, 2026
Tuesday, July 28, 20264:00 PM - 6:00 PMResearch Symposium Check-In Open

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Wednesday, July 29, 2026
Wednesday, July 29, 20267:00 AM - 5:30 PMResearch Symposium Check-In Open
Wednesday, July 29, 20268:30 AM - 8:50 AMWelcome & Opening Remarks
Wednesday, July 29, 20268:50 AM - 9:20 AMUnlocking Critical Periods of Brain Plasticity
Wednesday, July 29, 20269:25 AM - 9:55 AMTBA - To Be Announced
Wednesday, July 29, 202610:00 AM - 10:15 AMThalamocortical Mechanisms of Delta Oscillations in Ube3a^m-/p+ Mice
Wednesday, July 29, 202610:15 AM - 10:35 AMOpen Discussion & Break
Wednesday, July 29, 202610:35 AM - 11:05 AMTowards a Common Framework for UBE3A in Angelman Syndrome and Cancer
Wednesday, July 29, 202611:10 AM - 11:25 AMLoss of UBE3A Ligase Activity Drives Phenotypes in an Angelman Syndrome Mouse Model
Wednesday, July 29, 202611:25 AM - 12:30 PMLunch Break
Wednesday, July 29, 202612:30 PM - 1:00 PMFruit Flies for the Study of 15q Related Syndromes
Wednesday, July 29, 20261:05 PM - 1:20 PMInvestigating the Role of HERC2 and HERC2/UBE3A Synergy Toward the Pathogenesis of Dup15q Syndrome
Wednesday, July 29, 20261:25 PM - 1:55 PMContributions of UBE3A and Non-Imprinted Genes to Angelman Syndrome and Dup15q Syndrome Pathophysiology
Wednesday, July 29, 20262:00 PM - 2:30 PMWhat do (novel) AS mouse models inform us about UBE3A reinstatement treatments?
Wednesday, July 29, 20262:30 PM - 2:50 PMOpen Discussion & Break
Wednesday, July 29, 20262:50 PM - 3:20 PMNickase Cas9 Unsilences Paternal Ube3a in a Mouse Model of Angelman Syndrome Without Causing AAV Vector Integration
Wednesday, July 29, 20263:25 PM - 3:40 PMEpileptiform Spikes in Angelman Syndrome Improve in Response to the UBE3A-ATS Antisense Oligonucleotide Rugonersen
Wednesday, July 29, 20263:45 PM - 4:15 PMNeuronal UBE3A loss engages a TNF-driven neuron-to-microglia axis that promotes synaptic engulfment in Angelman Syndrome
Wednesday, July 29, 20264:20 PM - 4:50 PMAggression Circuit Mapping Across a Transsynaptic Complex in Idic(15) Model
Wednesday, July 29, 20264:55 PM - 5:25 PMGaining Insight Into Dup15q Using Human Induced Pluripotent Stem Cell Models
Wednesday, July 29, 20265:30 PM - 5:45 PMUtilizing CRISPR Pooled Screening to Identify Genetic Regulators of Paternal Ube3a Silencing
Wednesday, July 29, 20265:45 PM - 6:15 PMOpen Discussion & Break
Wednesday, July 29, 20266:15 PM - 8:15 PMASF & Dup15q Research Symposium Reception and Poster Presentation

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Thursday, July 30, 2026
Thursday, July 30, 20267:30 AM - 8:10 AMClosing Breakfast with ASF & DUP15Q Alliance
Thursday, July 30, 20268:00 AM - 8:10 AMOpening Remarks - Day 2
Thursday, July 30, 20268:10 AM - 8:40 AMNew Therapeutic Opportunities in Angelman Syndrome: How AI Is Changing Drug Discovery
Thursday, July 30, 20268:45 AM - 9:00 AMProgram Update on MVX-220
Thursday, July 30, 20269:05 AM - 9:20 AMResults of the Phase 2a Pediatric Study of Alogabat for the Treatment of Angelman Syndrome (ALDEBARAN Study)
Thursday, July 30, 20269:25 AM - 9:55 AMDevelopment of an ASO targeting UBE3A for Dup15q syndrome using a proprietary AI-enabled CNS drug discovery platform
Thursday, July 30, 20269:55 AM - 10:15 AMOpen Discussion & Break
Thursday, July 30, 202610:15 AM - 10:45 AMOverview of the Requirements for a High-Quality Stem Cell Bank
Thursday, July 30, 202610:50 AM - 11:20 AMPreclinical Testing of an ASO Therapy for Dup15q Syndrome
Thursday, July 30, 202611:25 AM - 11:40 AMA Dosage-Sensitive In Vitro Platform for the Quantification of UBE3A-Driven Network Dysfunction and Therapeutic Rescue in Duplication 15q Syndrome
Thursday, July 30, 202611:45 AM - 12:15 PMModel Systems for Evaluating Therapeutic ASOs
Thursday, July 30, 202612:20 PM - 12:35 PMComparison of Clinical-Stage ASOs for the Treatment of Angelman Syndrome in a Novel Humanized Ube3a-ATS Mouse Model
Thursday, July 30, 202612:35 PM - 1:35 PMLunch Break
Thursday, July 30, 20261:35 PM - 2:05 PMEvaluation of Individuals With Unsolved Imprinting Conditions Using Long-Read Sequencing
Thursday, July 30, 20262:10 PM - 2:25 PMFrom Pilots to Practice: Exploring and Advancing Newborn Screening for Angelman Syndrome
Thursday, July 30, 20262:30 PM - 2:45 PMCharacterizing the Angelman Syndrome Sleep Phenotype: Intact Homeostatic Regulation Amidst Impaired Spectral Dynamics and Abnormal Spindle Activity
Thursday, July 30, 20262:50 PM - 3:05 PMSleep in Young Children with Angelman Syndrome
Thursday, July 30, 20263:10 PM - 3:25 PMCharacterization and Quantitation of Movement Disorders in Angelman Syndrome
Thursday, July 30, 20263:30 PM - 4:00 PMRace, Income, and Representation in Angelman syndrome: Implications for Phenotype Characterization, Care Access, and Trial Design
Thursday, July 30, 20264:00 PM - 5:30 PMResearch Symposium Open Discussion / Break
Thursday, July 30, 20264:30 PM - 5:30 PMAS Natural History Study 20 Year Celebration