Date
Wednesday, July 29, 2026
Time
3:25 PM - 3:40 PM (MDT)
Name
Epileptiform Spikes in Angelman Syndrome Improve in Response to the UBE3A-ATS Antisense Oligonucleotide Rugonersen
Description
Dr. Joerg Hipp Submitted:
Epilepsy is highly prevalent in AS. Epileptiform abnormalities as measured in the EEG and seizures reflect altered neuronal excitability characteristic of epilepsy, while interictal epileptiform discharges represent a subclinical manifestation of this state that may serve as a biomarker. Here we present work that quantifies and characterizes epileptiform discharges (spikes) in AS, investigates the relationship to characteristically abnormal EEG delta oscillations and tests for a response to rugonersen, an investigational drug that reinstates UBE3A in neurons.
Location Name
Colorado B
Speakers
Moderator(s)
Becky Burdine, Dylan Ritter
Session Type
Abstract