Date
Wednesday, July 29, 2026
Time
11:10 AM - 11:25 AM (MDT)
Name
Loss of UBE3A Ligase Activity Drives Phenotypes in an Angelman Syndrome Mouse Model
Description
Joseph Krzeski Submitted:
Loss of UBE3A ligase activity is sufficient to cause AS, but the extent to which this deficit drives AS phenotypes remains unclear. Using the UBE3A YFP mouse, we show that ligase-dead UBE3A recapitulates both behavioral and molecular phenotypes observed in full Ube3a deletion AS model mice.
Location Name
Colorado B
Speakers
Moderator(s)
Becky Burdine, Dylan Ritter
Session Type
Abstract