J.B. Le Pichon's main areas of interest include neurogenetics and epilepsy. His clinical practice focuses on children with rare neurological diseases including neurodegenerative disorders, neurocutaneous disorders, mitochondrial disorders, and Angelman Syndrome. Research projects that he has participated in focus mostly on epilepsy and neurogenomics. He is currently the co-Principal Investigator on a four year HRSA funded grant to develop medical homes for children with epilepsy in rural Kansas (this project was extended for a fifth year with additional funding).

He also has a strong interest in global medicine. He joined efforts with a group of US and Nigerian physicians in northern and central Nigeria to better understand the pathophysiology of acute bilirubin encephalopathy and kernicterus spectrum disorders (a major cause of mortality and morbidity in Nigeria). In December of 2022 he launched the Angelman Syndrome initiative at Children's Mercy in Kansas City. This is an initiative that is a joint effort led in close cooperation with a group of parents of children with Angelman Syndrome. As a result of this effort several clinical and research projects have evolved including the clinic itself, and several research projects targeting both applied and basic research. Doctor Le Pichon also greatly enjoys teaching and mentoring. He was the program director for the child neurology residency from 2010 to 2021.

He has received several rewards for his teaching and mentoring work, including the Daniel Scagliotti Teaching Award in 2014 and the Excellence in Teaching in Resident Education Award in 2021. In June of 2023 he completed a rigorous course in non-directive coaching from the Berkley Executive Coaching Institute and is currently working toward completion of his certification. Finally, Dr. Le Pichon holds several administrative positions including the director of research for the neurology division and the associate director for the Division of Neurology.